18 results
Metformin - First Line Treatment for Diabetes Type 2
• Start with initial dose of 500 mg
Treatment for Diabetes ... gastrointestinal (GI) adverse effects ... form and consider using ... Indications #Titration #Pharmacology ... #Diabetes #DM2
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... disease Common Side Effects ... #Metformin #Pharmacology ... #Summary #DM2 # ... diabetes #endocrinology
Sulfonylureas - Pharmacology Summary
Mechanisms of Action: Binds to the ATP-sensitive potassium channel in pancreatic beta cells,
Sulfonylureas - Pharmacology ... CKD Common Side Effects ... Sulfonylureas #Pharmacology ... #Summary #DM2 # ... diabetes #endocrinology
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors - Pharmacology ... ) Common Side Effects ... • Euglycemic diabetic ... #Summary #DM2 # ... diabetes #endocrinology
Estimating the Total Daily Dose (TDD) of Insulin: Weight-Based Dosing
TDD in units of insulin = N
: Weight-Based Dosing ... #TDD #Insulin #dosing ... Weight #Based #pharmacology ... endocrinology #diabetes ... #DM2
Algorithm for Metformin Prescribing and Dosing in CKD
Dose Initiation - Immediate release:
 • Initial 500 mg
Prescribing and Dosing ... • If Gl side effects ... #Prescribing #Dosing ... #CKD #pharmacology ... #algorithm #diabetes
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
Normal and Renal Dosing ... Inhibitors #Renal #Dosing ... #Pharmacology # ... Management #Diabetes ... #DM2 #Endocrinology
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
class of anti-diabetic ... Side effects include ... SGLT2 #Inhibitors #Pharmacology ... #Medications #DM2 ... #Diabetes #Endocrinology
GLP-1 Agonists

Adlyxin (Lixisenatide) Daily
Bydureon (Exenatide ER) Weekly 
Ozempic (Semaglutide) Weekly 
Trulicity (Dulaglutide) Weekly 
Victoza (Liraglutide) Daily
to treat Type 2 Diabetes ... Common side effects ... GLP1 #Agonists #Pharmacology ... #Dosing #Diabetes ... #DM2 #Endocrinology
GLP-1 Receptor Agonists - Pharmacology Summary
Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
Receptor Agonists - Pharmacology ... Toxicities: • Gl side effects ... Receptor #Agonists #Pharmacology ... #Summary #DM2 # ... diabetes #endocrinology