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diabetes dm2 diagnosis inhibitors pathophysiology psychiatry signs symptoms dosing glp1 medications summary adverse antipsychotics comparison exogenous glftap inpatient macroadenoma management
DPP-4 Inhibitors - Pharmacology Summary Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
- Pharmacology ... GLP-I receptor agonist ... failure Common Side Effects ... #Inhibitors #Pharmacology ... DM2 #diabetes #endocrinology
Mechanism of Action for Common Diabetes Medications • SGLT2i (Dapagliflozin) • TZD (Pioglitazone) • Biguanides (Metformin)
GLP-1 Receptor Agonists ... • DPP4i / Gliptins ... #Medications #pharmacology ... pathophysiology #endocrinology
Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds
Mechanisms and Side Effects ... Receptor Partial Agonist ... to D2-receptor agonism ... ThirdGeneration #Mechanisms #SideEffects ... #pharmacology #
Exogenous Testosterone Side Effects • Mood disorder, Depression, Aggression • ↑ Erythropoiesis • Hypogonadism +/-BPH, prostate
Testosterone Side Effects ... #Testosterone #SideEffects ... adverse #diagnosis #signs ... symptoms #steroids #endocrinology
DPP4 Inhibitors - Normal and Renal Dosing Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
DPP4 Inhibitors ... titrate up to effects ... only few side effects ... Renal #Dosing #Pharmacology ... Diabetes #DM2 #Endocrinology
GLP-1 Agonists Adlyxin (Lixisenatide) Daily Bydureon (Exenatide ER) Weekly Ozempic (Semaglutide) Weekly Trulicity (Dulaglutide) Weekly Victoza (Liraglutide) Daily
GLP-1 Agonists ... Common side effects ... very similar to DPP4s ... #Pharmacology #Dosing ... Diabetes #DM2 #Endocrinology
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects • Serotonin Syndrome: - Autonomic Hyperactivity:
Mechanisms and Side Effects ... Pathophysiology #Pharmacology ... #SideEffects #Psychiatry ... #Diagnosis #Signs
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting Serotonin Syndrome - Potentially Life
Mechanisms and Side Effects ... Pathophysiology #Pharmacology ... #SideEffects #Psychiatry ... #Diagnosis #Signs
GLP-1 Receptor Agonists - Pharmacology Summary Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
GLP-1 Receptor Agonists ... - Pharmacology ... GLP1 #Receptor #Agonists ... #Pharmacology # ... DM2 #diabetes #endocrinology
Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist Dosing: 3 mg daily x 30 days, then 7 mg
First Oral GLP-1 Agonist ... only) oral GLP1 agonist ... empagliflozin and DPP4 ... semaglutide #Diabetes #Pharmacology ... #Endocrinology
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