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diagnosis hematology causes algorithm anemia bleeding bruising classification disorders hemophagocytic hlh lymphohistiocytosis thrombocytopenia treatment aflp aplastic blood dermatology dili drug
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
- Quantitative Defect ... Sequestration Disordered Platelet ... - Qualitative Defect ... Iatrogenic) • Liver ... Algorithm #Causes #Hematology
Platelet Disorders - Differential Diagnosis Framework Qualitative Defects: • Adhesion • Aggregation • Secretion Quantitative Defects: • Production:
Platelet Disorders ... - Differential ... Qualitative Defects ... • Production: Liver ... #Diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... deficiency • Liver ... Vasculopathy #Purpura #Differential ... #Diagnosis #hematology ... #rheumatology #
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... • Membrane defects ... Extrinsic Causes: • Liver ... , spider/snake bites ... classification #hematology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... less common, only affects ... ongoing ↑ LFTs or symptoms ... Idiosyncratic #differential ... gastroenterology #hepatology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... and symptoms: ... bleeding from low platelets ... Anemia #diagnosis #management ... #treatment #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Disorders - Differential ... : INR/PT, aPTT(liver ... pylori test (GI symptoms ... bypass), LFT (liver ... Causes #Workup #hematology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pathophysiology: • Defect ... postpartum): • Initial symptoms ... infiltration) Differential ... #Pregnancy #hepatology ... obgyn #diagnosis #management
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... or Qualitative defect ... in platelets == ... characteristic of a platelet ... #Diagnosis #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Diagnosis: HLH signs ... and symptoms can ... lymph node, or liver ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
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