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Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
TTP/HUS, HELLP Syndrome ... Pregnancy (AFLP) Three syndromes ... with coagulation defects ... Severe coagulation defects ... AFLP #obstetrics #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... Non-immune: Membrane Defects ... Spiders - Enzyme Defects ... - Hemoglobin Defects ... Differential #Diagnosis #hematology
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Pregnancy Three syndromes ... with coagulation defects ... Severe coagulation defects ... Obstetrics #OBGyn #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... Intrinsic RBC Defects ... thalassemias), Membrane defects ... differential #diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Thrombocytopenia • Platelet defects ... PURPURA: Platelet Defects ... Kasabach-Merritt syndrome ... Coagulation Defects ... Gardner-Diamond syndrome
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Qualitative Platelet Defects ... Bernard-Soulier Syndrome ... Grey Platelet Syndrome ... Inherited #Platelet #Defects ... differential #diagnosis #hematology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... Hyperviscosity Syndrome ... • Neurologic deficits ... Superior Vena Cava Syndrome ... : Tumor Lysis Syndrome
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
Hypereosinophilic Syndrome ... Hypereosinophilic Syndrome ... suspect underlying hematologic ... Hypereosinophilic #Syndrome ... #HES #Hematology
Incomplete spinal cord syndromes (ISCS) • Central - Small Lesion - Suspended sensory deficit, classic cape
Incomplete spinal cord syndromes ... Suspended sensory deficit ... type) and sensory deficits ... extremities, LMN deficit ... Incomplete #spinalcord #syndromes
Pathophysiology of Hemolytic Anemia - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects) -
Hemolytic Anemia - Defects ... and metabolic defects ... ) - Defects in ... rnembranes - Defects ... Hemolytic #Anemia #hematology
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