14 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... - APLS • Acute ... Gardner-Diamond syndrome ... Differential #Diagnosis #hematology ... #rheumatology #
Hepatorenal Syndrome (HRS) - Diagnostic Criteria
HRS-AKI (Acute: previously known as HRS Type 1)
 • ↑ Creatinine
Hepatorenal Syndrome ... Criteria HRS-AKI (Acute ... structural kidney injury ... haematuria, Normal renal ... HRS-NAKI (Non-Acute
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Causes of Knee Effusions ... bearing after injury ... Loss of sensation distal ... - Acute rheumatic ... Knee #Effusions #causes
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... - ACS, AKI, acute ... : • Pathophysiology ... diagnosis #management #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Renal Failure ... Differentiation #Syndrome ... diagnosis #management #hematology
Hydroxychloroquine - Risks and Benefits in Lupus
Benefits:
↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
SSA-associated fetal ... - Cuteanous: acute ... of renal or hepatic ... Benefits #Lupus #pharmacology ... #sideeffects #rheumatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
• Nephrotic Syndrome ... coagulation and other causes ... Vasculitis • Injury ... Venous #Arterial #pathophysiology ... #hematology #differential
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... lubricants • Pharmacologic ... #Rheumatology #
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
malignancy (Especially acute ... protein C and S Pathophysiology ... Bleeding (64%) • Renal ... Treat primary cause ... treatment #management #hematology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
Crisis: 1) Acute ... kidney injury ... anemia (MAHA) Pathophysiology ... • Refractory cases ... #Crisis #rheumatology