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diagnosis differential oncology management algorithm causes lupus monoclonal systemic erythematosus gammopathy skin vasculitis anemia chronic clinical disease idiopathic leukemia rash
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
capillary leak syndrome ... • Schnitzler syndrome ... Cryoglobulinemia Renal-centered ... #Significance #MGUS ... Differential #Diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... Associated - SLE ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... • MGCS • MGRS ... capillary leak syndrome ... vascular beds-renal ... Paraproteinemias #Hematology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Malar rash • SLE ... IBD • RA • SLE ... Antiphospholipid-antibody syndrome ... Sarcoidosis #dermatology ... differential #diagnosis #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Autoimmune • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... Algorithm #Causes #Hematology
Scleroderma Associated Telangiectasia. If you see them-round, often well circumscribed (but can be matte-like too) &
If you see them-round ... especially SSc, SLE ... Telangiectasia #clinical #video ... blanching #skin #dermatology ... #rheumatology
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 Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
severe disease & renal ... block • Sjogren syndrome ... polymyositis overlap syndrome ... • Specific for SLE ... Summary #diagnosis #rheumatology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Significance (MGUS ... Summary Framework Hematologic ... sub-types based on the hematologic ... hyperCalcemia, Renal ... #Significance #hematology
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
hemolytic-uremic syndrome ... • Scleroderma renal ... anemia" • HELLP syndrome ... differential #diagnosis #hematology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Secondary: CTD: SLE ... Disease • Cogan syndrome ... Vasculitis #skin #dermatology ... #rheumatology #
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