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diagnosis algorithm oncology clinical pathology smear thrombocytosis apl auer basophilia basophils cancer differentiation disorders eosinophilia gap globulin hypersegmented increased lymphomas
Hypersegmented neutrophil in a case of acute myeloid leukemia. Dysplastic neutrophils are typically hypolobated but can be
Hypersegmented neutrophil ... in a case of acute ... myeloid leukemia ... #AML #Clinical ... #Hematology #Pathology
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
Acute promyelocytic ... leukemia (blood ... features in most cases ... #APL #APML #Pathology ... #Hematology #Clinical
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Causes of Neutrophilia ... - Differential ... Polycythemia vera Acute ... #Differential # ... #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... ALL (Acute Lymphoblastic ... -> AML: Blast crises ... Leukemia): • Neutrophils ... #Hematology #Oncology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential ... Chronic Myelogenous Leukemia ... Infectious: • Acute ... disorders • Celiac ... #Hematology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
- Differential ... Rhinitis - Allergic Dermatitis ... Primary: - CML ... Mastocytosis - Acute ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... Incidence: common in APL ... febrile neutrophilic ... Differentiation #Syndrome #APML ... diagnosis #management #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential ... Thrombocytosis): • Acute ... Chronic myeloid leukemia ... (CML) - Dr. ... #hematology #secondary
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... (CML) - associated ... translocation • Acute ... #Diagnosis #causes ... #hematology #basophils
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Treated Like Acute ... Leukemias, very ... relapse - Amy ... Lymphoproliferative #Disorders #Classification ... pathophysiology #Hematology
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