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antinuclear autoantibodies erythematosus workup abnormal algorithm alopecia antineutrophil aortitis aptt arthritis associations autoimmune coagulation cryoglobulinemia cryoglobulins disease disorders glomerulonephritis hair
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... ) • Systemic lupus ... in drug-induced SLE ... #antibodies #diagnosis ... #rheumatology #
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... (SLE), Systemic ... #ANA #patterns ... #rheumatology #diagnosis ... #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
: The ANA patterns ... (SLE), Systemic ... : Lupus (SLE), Systemic ... #ANA #patterns ... #rheumatology #diagnosis
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... ANA (anti-nuclear ... Vasculitis: P-ANCA ... Autoantibodies #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Diagnosis: Systemic ... ) pattern: antibodies ... , and SLE) • Urinalysis ... differential #diagnosis ... #rheumatology #
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Nodosa (PAN), ANCA ... Arthritis (RA), Systemic ... lupus erythematosus ... (SLE), Sarcoidosis ... #Diagnosis #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Pigmented Purpuric Dermatosis ... Cryoglobulinemia (MIXED) • ANCA ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Negative IF): • PR3-ANCA ... (C-ANCA): GPA > ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA, ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Classification: ... Diagnosis: • ANCA-associated ... #Systemic #Lupus ... #Rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... : - ANA 95-100% ... Diagnosis and Lupus ... #Systemic #Lupus ... #rheumatology
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