Dermatitis skinrash lupus clinical syndrome rheumatology sle management erythematosus disease patterns table diagnosis antineutrophil anca ana summary differential cerebritis

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ANA Patterns and Associated Rheumatic Diseases:
• Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease

ANA Patterns and ... Syndrome (SS), Polymyositis ... Antinuclear #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

likely it will be clinically ... : The ANA patterns ... : Lupus (SLE), Systemic ... #patterns #rheumatology ... #diagnosis #differential

CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic

SLE) Clinical ... Demyelinating Syndrome ... of Lupus Cerebritis ... #rheumatology # ... cerebritis #diagnosis

Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
• Epidemiology: 10-180/100,000, Typically Age 20-40, F:M

Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... Workup: - ANA ... #Diagnosis #Management ... #Summary #rheumatology

Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
• Associated

Systemic Lupus Erythematosus ... (ANA) - 95% - Initial ... #SLE #Summary #diagnosis ... #rheumatology # ... management

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

SLE (Systemic Lupus ... alopecia Differential ... Diagnosis: • ANCA-associated ... Serositis Labs: • ANA ... #Diagnosis #Rheumatology

Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

Others: • Lupus ... such as systemic lupus ... erythematosus, ... SLE) • Urinalysis ... #diagnosis #rheumatology

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

searched for when ANA ... overlap syndromes ... #erythematosus ... #diagnosis #rheumatology ... #table #ANA

Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
• Epidemiology: -10% of all lupus cases, drug-dependent,

Workup: - ANA ... Erythematosus ( ... Workup: - ANA ... #table #rheumatology ... #diagnosis #management

Cryoglobulinemia Summary

Cryoglobulins:
• Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below

Cryoglobulinemia Summary ... : • Clinical triad ... DDX: • ANCA (Antineutrophil ... (e.g. systemic lupus ... erythematosus (

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