22 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
of Systemic Lupus ... Cerebrovascular Disease ... autoantibodies that will cause ... #SLE #CNS #neurology ... #rheumatology #
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
(CNS) involvement ... less common diseases ... Vogt-Koyanagi-Harada (VKH) disease ... disease • Multiple ... BEE #Syndromes #neurology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
lupus erythematosus ... connective tissue disease ... 90% • Anti-GBM disease ... #rheumatology # ... diseases
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Disease, Polyarteritis ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... (SLE), Sarcoidosis ... #rheumatology
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
lymphoproliferative disease ... • Metastatic disease ... demyelinating diseases ... #causes #radiology ... #neurology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... Evolution: Chronic disease ... #lupus #Systemic ... Management #Summary #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... diseases (i.e. ... and CNS • Headache ... #Systemic #Lupus ... #Rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome Systemic ... disease associated ... skin injury) • Neurologic ... signs #symptoms #rheumatology ... #disease
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... et diutinum Neurologic ... to cold IgG • Lupus ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
suspicion of severe disease ... guidelines General - Systemic ... splenomegaly, abnormal neurology ... - Sickle cell disease ... Rheumatology