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differential systemic ana anca antibodies antibody antineutrophil antinuclear aortitis cerebritis cryoglobulinemia cryoglobulins diseases monoclonal neurology oncology paraproteinemias signs sjogrens symptoms
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis ... #Diagnosis #Rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... ANCA associated vasculitis ... erythematosus ( ... SLE), Sarcoidosis ... #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Cerebrovascular Disease ... #SLE #CNS #neurology ... #rheumatology # ... #management #treatment
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... erythematosus, ... , and SLE) • Urinalysis ... #rheumatology # ... classification
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... Abdominal pain (20%) Renal ... disease (30%): ... #erythematosus # ... #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... erythematosus ... ANCA-Associated Vasculitis ... vasculitis - MPO ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• IgA vasculitis ... • Vasculitis ... erythematosus ( ... #rheumatology # ... vasculitis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Scleromyxedema (CNS ... Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... to cold IgG • Lupus ... Paraproteinemias #Hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulmonary and renal ... , such as SLE, atherosclerotic ... ischemia • Skin: Erythematous ... chorioretinitis, CNS ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
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