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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
in Systemic Lupus ... #diseases #SLE ... #Systemic #Lupus ... #nephritis #classification ... #types #rheumatology
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of ... - Kawasaki disease ... and infectious diseases ... lupus erythematosus ... #Diagnosis #Rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Butterfly rash, Vasculitis ... Abdominal pain (20%) Renal ... disease (30%): ... ) Blood (75%): Anemia ... symptoms #diagnosis #rheumatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Differential Diagnosis Algorithm ... Cholestatic liver disease ... BUN: • Chronic renal ... failure/uremia ... syndrome Psychiatric Disease
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
of Chronic Disease ... of Chronic Disease ... Renal Disease, Liver ... Disease, Endocrinopathy ... #MCV #Classification
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
pain • Kawasaki Disease ... (Granulomatous disease ... rheumatic diseases ... atherosclerotic disease ... most important diseases
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Peripheral edema, Disease-specific ... , Behcet disease ... lupus erythematosus ... Goodpasture's Disease ... dysmorphic RBCs) • Disease-specific
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
lupus erythematosus ... connective tissue disease ... 90% • Anti-GBM disease ... antibodies #diagnosis #rheumatology ... #diseases
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Clinical Classification ... Chronic hemolytic anemia ... Systolic dysfunction ... neurofibromatosis, vasculitis ... mediastinitis, chronic renal
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
ASA) • Renal Disease ... • Steroids • Vasculitis ... Von Willebrand's Disease ... Iatrogenic) • Liver Disease ... #Causes #Hematology