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differential rheumatology syndrome oncology clinical erythematosus hematology management symptoms autoantibodies behcet classification dermpath lesions macrophage mas mimickers monoclonal myelodysplastic paraproteinemias
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
Cutaneous manifestations ... appearing during the disease ... Neutrophilic dermatosis ... dermatomyositis, SLE ... #dermatology #oncology
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Connective tissue disease ... (10%) : SLE +++ ... #signs #lesions ... #diagnosis #clinical ... #manifestations
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... - Diagnosis Manifestations ... , Cutaneous mimickers ... #Systemic #Lupus ... autoantibodies #signs
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Differential Diagnosis ... Chronic B-cell activation ... #Systemic #Lupus ... Erythematosus #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... aphthous ulcers, cutaneous ... as systemic lupus ... purpura: strong sign ... , and SLE) • Urinalysis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... • Neutrophilic dermatosis ... gangrenosum • Cutaneous ... to cold IgG • Lupus ... #Differential #Diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... • Systemic lupus ... lupus erythematosus ... [SLE], AOSD) • ... #Syndrome #Diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... as SLE, atherosclerotic ... purpura: Strong sign ... - interstitial keratitis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome Systemic ... M > F Clinical Manifestations ... ) • Cutaneous Lesions ... Oral aphthae : SLE ... #management #signs
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
disease. ... Most common extra cutaneous ... Episcleritis Signs ... ’s syndrome - Lupus ... #dermatology #oncology
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