22 results
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
tissue disease ... Syndrome (SS), ... (SLE), Systemic ... Kumfer @AnnKumfer #Antinuclear ... #rheumatology #diagnosis
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... (SLE), Systemic ... : Lupus (SLE), Systemic ... Lymphoproliferative Disorders ... #rheumatology #diagnosis
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
Discoid Rash A Antinuclear ... Neurological Disorders ... Arthritis R Renal Disease ... #IMDAMNSHARP #sle ... #systemic #lupus
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... block • Sjogren syndrome ... #Lupus #Erythematosus ... diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... Association with disease ... overlap syndromes ... #diagnosis #rheumatology
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
- Differential Diagnosis ... arthritis - (Reiter’s syndrome ... Lupus - with Systemic ... Lupus Erythematosus ... (SLE), should have
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... (SLE) Clinical ... Demyelinating Syndrome ... Cerebrovascular Disease ... #SLE #CNS #neurology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
central nervous system ... • Systemic lupus ... optica spectrum disorder ... #neurology #inflammatory ... #differential #diagnosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... lupus erythematosus ... in drug-induced SLE ... cases • Sjögren syndrome ... Antineutrophil #antibodies #diagnosis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Differential Diagnosis ... ) • Endocrine disorders ... #Systemic #Lupus ... Erythematosus #Diagnosis