11 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... of Systemic Lupus ... #Lupus #Erythematosus ... #SLE #CNS #neurology ... #rheumatology #
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
• Contact dermatitis ... pemphigoid • Dermatitis ... • Bullous systemic ... lupus erythematous ... Vesiculobullous #SkinRash
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 1 • Clinical Manifestations ... Positive in 60-80% of cases ... #Systemic #Erythematosus ... Management #Summary #rheumatology
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
NMO) - Clinical Manifestations ... pain • Extra-CNS ... autoimmune disorders (Systemic ... lupus erythematosus ... #diagnosis #neurology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
central nervous system ... (CNS) involvement ... Inflammatory causes ... lupus erythematosus ... BEE #Syndromes #neurology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
& Mu) Skin Manifestations ... • Neutrophilic dermatosis ... Neurologic Manifestations ... to cold IgG • Lupus ... Subcorneal pustular dermatosis
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... Discontinuation of causal ... months to years) Systemic ... Lupus Erythematosus ... comparison #table #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lupus erythematosus ... main clinical manifestation ... (CNS) dysfunction ... lupus erythematosus ... #Rheumatology
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... pericarditis » is...lupus ... to unexplained manifestations ... #system #erythematosus ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... inflammation Others: • Lupus ... ischemia - Skin: erythematous ... lupus erythematosus ... differential #diagnosis #rheumatology