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algorithm anemia management coagulation comparison intravascular table thrombocytosis workup abnormal aflp bleeding blood bruising classification extravascular hellp hemolytic mcv obstetrics
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
purpura/hemolytic ... uremic syndrome ... , Hematology 2012 ... , p 193 #Diagnosis ... #Differential #
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... syndrome (ST-HUS ... • Severe B12 deficiency ... anemia" • HELLP syndrome ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... G6PD deficiency) ... #differential # ... diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... Diagnosis Algorithm ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential ... Diagnosis Algorithm ... • PK deficiency ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential ... Diagnosis Algorithm ... following EtOH induced thrombocytopenia ... malignancy • Iron deficiency ... #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
, Pulmonary emboli ... Thrombotic idiopathic thrombocytopenia ... Morphology #Atlas #key #diagnosis ... #differential # ... hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
specifically: iron deficiency ... , hemolysis, hemorrhage ... Myelodysplastic syndrome ... #Diagnosis #Causes ... #hematology #secondary
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... Schistocytes, thrombocytopenia ... #Anemia #Differential ... #workup #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Diagnosis Congenital ... Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
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