Diagnosis classification hematology pocus algorithm evaluation hepatology disorders anemia pancytopenia failure bleeding protein

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Aplastic Anemia and Bone Marrow Failure Syndromes with Pancytopenia

Fanconi Anemia
Acquired Aplastic Anemia
Dyskeratosis Congenita & Telemore Biology

and Bone Marrow Failure ... Syndromes with Pancytopenia ... Telemore Biology Disorders ... lauraebrown #Pancytopenia ... #diagnosis #Hematology

Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
1. Autoimmune Mediated Pancytopenia
2. Splenic Sequestration
Peripheral Destruction

Algorithm Consumption ... Disorders 1. ... Acquired Aplastic Anemia ... Congenital bone marrow failure ... #Algorithm #Hematology

Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80

Algorithm Low ... 80-100 fL) • Bleeding ... Hemolysis • Marrow Failure ... #MCV #Classification ... #Hematology

Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
• Decreased Production
•

Causes of Bleeding ... - Differential Diagnosis ... Algorithm Thrombocytopenia ... Sequestration Disordered ... #Hematology

Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
- Prior platelet count, family

- Differential Diagnosis ... changes), high MCV anemia ... - Bone marrow evaluation ... ITP, unexplained pancytopenia ... Causes #Workup #hematology

Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
• Acute Bleed - Normocytic / Normochromic

- Differential Diagnosis ... Algorithm Blood ... #Classification ... #Algorithm #Causes ... #Hematology

Indications for Serum Protein Electrophoresis (SPEP)
• Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related

amyloidosis, or related disorder ... • New-onset anemia ... pain, abnormal bleeding ... Electrophoresis #SPEP #Hematology ... #Diagnosis

Causes of Pleural Effusion - Differential Diagnosis Algorithm
Transudate - Hydrostatic
• Congestive heart failure
• Constrictive

- Differential Diagnosis ... Algorithm Transudate ... Congestive heart failure ... Nephrotic syndrome • Protein-losing ... #Algorithm #Hepatology

Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations

bone morphogenic protein ... Chronic hemolytic anemia ... multifactorial mechanisms Hematologic ... chronic renal failure ... #Diagnosis #Differential

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