23 results
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome:
 - Acute poststreptococcal 
glomerulonephritis 
 - Rapidly progressive
Glomerular Diseases ... Nephrotic Syndromes ... Nephritic syndrome ... Nephrotic syndrome ... #Nephrotic #Syndromes
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
Glomerular Diseases ... Nephrotic Syndromes ... RBC casts in urine ... #Nephrotic #Syndromes ... #Nephrology #Diagnosis
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Syndrome Step ... /nephritic syndromes ... #Syndrome #Comparison ... #Algorithm #Nephrology ... #Diagnosis
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
GN • Active Urine ... dysmorphic RBC, RBC casts ... , +/- proteinuria ... anti-phospholipid syndrome ... #MPGN #nephrology
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
hemolytic-uremic syndrome ... cell/white cell casts ... #glomerular #proteinuria ... #nephrotic #syndrome ... #nephrology
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
nephrolithiasis • Symptoms ... bleeding (proteinuria ... , RBC casts, dysmorphic ... → Refer to Nephrology ... cystoscopy • Refer to Nephrology
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
and concentrated urine ... Red blood cell - Glomerulonephritis ... syndrome ("Maltese ... edgarvlermamd - Nephrology ... #Nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Fanconi's syndrome ... • Drugs Glomerular ... sediment - WBC/RBC casts ... Minimal change disease ... #Nephrology #Differential
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
chronic kidney diseases ... suggestive of nephrotic ... sydnrome • Pigment ... #nephrology #interpretation ... #diagnosis
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
- Alport syndrome ... pain hematuria syndrome ... - Proteinuria ... • Nutcracker syndrome ... #nephrology #renal