Diagnosis workup table signs hematology dermatology treatment syndrome hemolysis ttp purpura anemia

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Hemolytic Anemia - Hemolysis Diagnostic Workup

Infographic by: Howard Ong

#Hemolysis #Hemolytic #Anemia #Algorithm #MAHA #TTP #Diagnosis #Workup

Hemolytic Anemia ... - Hemolysis Diagnostic ... #Hemolytic #Anemia ... #Diagnosis #Workup ... #Hematology

Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film.
TTP/HUS indicates thrombotic

Algorithm for workup ... TTP/HUS indicates ... /hemolytic uremic ... syndrome. ... thrombocytopenia, Hematology

Differential diagnosis of schistocytes / fragmentation hemolysis:
• Thrombotic microangiopathies (TMA)
- TTP

Differential diagnosis ... microangiopathies (TMA) - TTP ... syndrome (ST-HUS ... anemia" • HELLP ... #hematology #hemolysis

Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

Diagnostic Framework ... anemia): ... thrombocytopenic purpura ... (TTP), Hemolytic ... #hematology #anemia

Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage

Diagnosis Framework ... /HUS - Hemolytic ... anemia - Splenomegaly ... #hematology #rheumatology ... #nonpalpable #dermatology

Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,

distinction has HUGE treatment ... and first-line treatment ... thrombocytopenic #purpura ... thrombocytopenia #Comparison #Diagnosis ... #Table #Hematology

TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A

TTP - Laboratory ... Thrombocytopenic Purpura ... anemia Indirect ... impairment #TTP ... #Workup #Hematology

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia ... - Differential Diagnosis ... thrombocytopenia - DIC, TTP ... #Anemia #Differential ... #workup #hematology

Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?

→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... #Algorithm #hematology

Hemolysis - Differential Diagnosis Framework

1) Environment
- Fragmentation
- MAHA: TTP, HUS, DIC, HELLP

Diagnosis Framework ... Fragmentation - MAHA: TTP ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... #hematology

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