1238 results
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Liver Injury - Pathophysiology ... Indirect Idiosyncratic ... Direct BWH ... Liver #Injury #Pathophysiology
Biochemistry and Metabolism of Bilirubin
Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
"indirect bilirubin ... Unconjugated and "indirect ... conjugated and "direct ... Biochemistry #Metabolism #pathophysiology
Gonorrhea: Pathophysiology

 - Neonatal Transmission -> Direct contact of patient mucosa with mother's infected mucosa while
Gonorrhea: Pathophysiology ... Transmission -> Direct ... Transmission -> Direct ... patient mucosa via indirect ... #Gonorrhea #Pathophysiology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Hyperkalemia • Direct ... differential #diagnosis #pathophysiology
Major Physiological Effects of Angiotensin II

Altered Peripheral Resistance
I. Direct vasoconstriction
II. Enhancement of peripheral noradrenergic
neurotransmission:
  A.
Direct vasoconstriction ... Direct effect to ... Direct renal vasoconstriction ... AngiotensinII #Pathophysiology
Management of Medically Refractory Gastroparesis

Gastroparesis Pathophysiology
Initial Evaluation
Management
Medications for Medically Refractory Gastroparesis
Gastric Electrical Stimulation
Pylorus Directed Therapies

Dr. Chaitanya
Gastroparesis Pathophysiology ... Stimulation Pylorus Directed
Gastric Acid Secretion - Pathophysiology
Chief cell - Pepsinogen
Parietal cell - Acid, Intrinsic factor
G cell - Gastrin
Inhibitors:
Acid Secretion - Pathophysiology ... Distension by food directly ... Acid #Secretion #Pathophysiology
How does IAH/ACS result in systemic end organ dysfunction? Through direct transmission of intra-abdominal pressure

#Pathophysiology #ACS
Through direct transmission ... intra-abdominal pressure #Pathophysiology
Non-cirrhotic Hyperammonemia - Differential Diagnosis Framework

Hematologic & Vascular:
 • Multiple myeloma & Acute leukemia (plasma cells
- Infections (direct ... Differential #Diagnosis #Pathophysiology
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
cartilage means direct ... Osteoarthritis #OA #pathophysiology