31 results
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
sequestration and activation ... without other cause ... : 33% • Treatment ... : No • Treatment ... Transfusion #Reactions #hematology
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Inhibits plasminogen activation ... reduces complement activation ... : Urine Common Uses ... fatigue; Increases risk ... #Pharmacology #hematology
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients)
Important notes:
 • No
Bleeding risk calculators ... • No bleeding risk ... validated for VTE treatment ... #Scores #Calculators ... Anticoagulation #Factors #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... only curative treatment ... Myelodysplastic #Syndrome ... #hematology #oncology
4-T Score for the Likelihood of Heparin Induced Thrombocytopenia
 - Thrombocytopenia - Compare the highest platelet
count
4-T Score for the ... Other potential cause ... Low probability (risk ... High probability (risk ... Likelihood #Diagnosis #Hematology
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)
Major criteria 
 1. Abrupt onset of tender
for Sweet Syndrome ... an underlying hematologic ... Excellent response to treatment ... #Diagnosis #Hematology ... #Dermatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... Histopathologic criteria ... Treatment: • Corticosteroids ... MAS #Macrophage #Activation ... #Management #Hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
normal in mild cases ... ) • Classify severity ... Treatment - Acute ... that ↑ bleeding risk ... #hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
injection sites) ↑ Risk ... complex → plt activation ... • If 4T score ... Diagnosis #Management #Treatment ... #Hematology #HemeOnc
Approach to Elevated Tryptase - Differential Diagnosis Framework

The DDx of elevated tryptase can be broken down
pass = Primary Causes ... • Mast cell activation ... syndrome • Mastocytosis ... • Other hematologic ... Differential #Diagnosis #hematology