15 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
processes like primary biliary ... cirrhosis (PBC) ... erythematosus (SLE ... ) Signs / Symptoms ... #Signs #Symptoms
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary ... Cirrhosis - Diagnosis ... Algorithm Symptoms ... quadrant discomfort Signs ... #Cirrhosis #Diagnosis
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Anti-gp210 - Primary biliary ... cirrhosis (PBC) ... Anti-SSB (La) - Sjogren's ... Associations #diseases #diagnosis ... #table #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... ), Sjogren's Syndrome ... Hepatitis, Primary Biliary ... Cirrhosis, Drug-Induced ... #diagnosis #differential
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... Cirrhosis (PBC) ... failure PBC Signs ... and Symptoms: ... #workup #hepatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% SLE ... Labs/Diagnosis: ... erythematosus (SLE ... #types #classification ... #rheumatology #
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Systemic Lupus (SLE ... loss (50%) Eye: Sjögrens ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Post-Transplantation Lymphoproliferative Disorders (PTLD)
Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
Conditioning regimen Signs ... , unexplained hematologic ... EBV viral load, signs ... and classification ... Disorders #oncology #diagnosis
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA, SLE ... hepatitis, primary biliary ... cirrhosis: 3%-20% ... Nephrogenic DI Hematologic
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Differential Diagnosis ... dermatomyositis, Sjogren ... Kikuchi disease • Type-I ... Induced Lupus: • Symptoms