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diagnosis treatment differential algorithm barre guillain lupus proteinuria renal sle arteritis associated behcets cerebritis child classification cns crisis dermatology disease
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... RBC casts in urine ... but in severe cases ... May be 10 (eg direct ... #Proteinuria #Nephrology
Urine Microscopy - Casts Acellular Casts • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Acellular Casts ... suggestive of nephrotic sydnrome ... colored compounds (e.g ... heme, bilirubin, etc ... Urine #Microscopy #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... • Fanconi's syndrome ... sediment - WBC/RBC casts ... Protein deposition (eg ... #Proteinuria #Nephrology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
• Special cases ... (e.g. renal failure ... Measurement #SLE #rheumatology ... #pharmacology # ... levels #lupus #management
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY RED FLAGS - In all cases there are specific markers which
FLAGS - In all cases ... splenomegaly, abnormal neurology ... cell disease Rheumatology ... Pathway #Child #Peds
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Behcet's Syndrome ... Behcets #disease #Syndrome ... #Treatment #management ... #pharmacology # ... rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... autoantibodies that will cause ... Erythematosus #SLE #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis #management
Staphylococcus-associated GlomeruloNephritis - Diagnosis and Management Summary CLINICAL • Nephritic syndrome (Casts) • Marked proteinuria (may be
Diagnosis and Management ... • Nephritic syndrome ... (Casts) • Marked ... GlomeruloNephritis #nephrology ... #diagnosis #management
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Diagnosis and Management ... Prevalence: 1-2 cases ... autoantibodies - TPO, TTG, etc ... SPS #Diagnosis #Management ... #treatment #neurology
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... Epidemiology: • 1-2 cases ... Electrodiagnostic studies - EMG ... #diagnosis #management ... #treatment #neurology
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