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differential algorithm management anemia thrombocytopenia coagulation abnormal comparison injury prolonged pt aflp ascites bleeding blood bruising dermatology elevatedmcv hellp intravascular
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
K Antagonists, Heparin ... to identify the cause ... of Prolonged APTT ... #prolonged #diagnosis ... #hematology #evaluation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... • Reduced liver ... #hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... e.g. heparin ... Reduced liver synthesis ... #diagnosis #differential ... #hematology #coagulation
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
- Differential Diagnosis ... Sepsis • Drugs (e.g ... • Gilbert's Syndrome ... #Algorithm #Causes ... #Hepatology #bilirubinemia
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Medications - Heparin ... ) • Advanced Liver ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
Thromboplastin Time (PTT ... inhibitor • Liver ... elevated in: • Heparin ... Thromboplastin #laboratory #hematology ... #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... for alternative causes ... disease, Hepatic ... #Injury #Diagnosis ... #Algorithm #hepatology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Causes of Splenomegaly ... - Differential Diagnosis ... Hepatic, Portal, ... #Differential #Diagnosis ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... : INR/PT, aPTT(liver ... function test, ANA (e.g ... bypass), LFT (liver ... #hematology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... and hepatorenal syndrome ... • Budd Chiari syndrome ... sarcoidosis) • Liver ... #causes #hepatology
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