15 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... or symptoms of liver ... #differential #Diagnosis ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Tests (LFTs) - ... Differential Diagnosis ... (>1000): • DILI ... Function #Tests #LFTs ... #hepatology #transaminitis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... to HDS, drugs, OTC ... of information (e.g ... #Injury #Diagnosis ... #Algorithm #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
(LFTs) - Normal ... Values and Interpretation ... bilirubin (Conjugated/DBili ... Function #Tests #LFTs ... #diagnosis #hepatology
The Liver Consult Primer - Guide to calling a consult
HPI:
 - Start with reason for consult
- Vitals - LFTs ... GTT, indirect bili ... disease work up ... shock, sepsis, GIB etc ... Calling #Referral #Hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
(LFTs) Elevation ... abnormality vs bone Bili ... #FunctionTest #LFTs ... Transaminitis #diagnosis ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
- Interpretation ... of LFTs R-value ... #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... gastric bypass), LFT ... (liver disease) ... #hematology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Malabsorption (e.g ... ) • Advanced Liver ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... disease, Etc. ... valve induced, Etc ... #differential #diagnosis ... #hematology #microscopy