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management causes hyperkalemia neurology pharmacology potassium acidosis classification defects diuresis diuretics elevation encephalopathy epithelial excretion hyponatremia hypotonic inherited kidney lactate
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
(Heparin) • Sodium-channel ... shift of K (Succinylcholine ... #hyperkalemia #differential ... #diagnosis #pathophysiology ... #druginduced
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
- Na-K-2Cl cotransporter ... , K channel, Cl ... Defects #Kidney #Nephrology ... #Diagnosis #Differential ... #Table
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
algorithm Urine Na+K ... Cirrhosis, Nephrotic syndrome ... #Hyponatremia #differential ... #diagnosis #table ... #sodium #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Etiology: • Medications ... heparinized tube) • ECG ... Elimination (see Table ... STOP offending medications ... #potassium #nephrology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
• Diagnosis of ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology ... #Pharmacology #Medications ... #Table
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
(SPS) - Diagnosis ... Treatment: • ... others (botox, sodium ... #Management #treatment ... #neurology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... Diagnosis Framework ... Herpes, Coxsackie, etc ... per day until stable ... #nephrology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Reversible course Differential ... Electrolyte abnormality, Medication ... epilepticus Treatment ... underlying cause • Treatment ... #neurology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... hypoxemia/Sepsis etc ... before beginning treatment ... - Compartment syndrome ... - HIV/HAART medications
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