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diagnosis differential management reactions algorithm comparison product rheumatology anemia cerebritis coagulation cryofibrinogenemia disorders disseminated elevatedmcv eosinophil eosinophilia erythematosus intravascular leukemia
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... transfusion • ... Thromboembolism (7%) • CNS ... Treat primary cause ... #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... in recipient (e.g ... pain, dark urine, DIC ... haptoglobin, ↑LDH, etc ... diagnosis #management #hematology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
of high parity blood ... without other cause ... : 33% • Treatment ... #Reactions #hematology ... diagnosis #comparison #table
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... thrombosis and/or blood-brain ... Lumbar Puncture, EEG ... Treatment:
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... pain, dark urine, DIC ... haptoglobin, ↑LDH, etc ... Causes purpura & ... diagnosis #management #hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Blood Loss, Occult ... 18% • Anemia Secondary ... HgbE, HgbC, etc. ... #Hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
• Peripheral blood ... • Screen for secondary ... glucocorticoid treatment ... signs or symptoms (eg ... Differential #diagnosis #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
which can plug blood ... cryoglobulin (CG ... cryoglobulins • Negative causes ... skin necrosis • DIC ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... -> AML: Blast crises ... Fibrinolysis & DIC ... bone marrow and secondary ... #Leukemia #Hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
hypertension and/or drug treatment ... Constitutional disorders, eg ... drug reactions - Secondary ... including white blood ... #hematology
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