43 results
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Drug-associated, PCH ... #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... Cold AIHA • Alloimmune ... Cold AIHA • PCH ... Prosthetic heart valves ... #Hematology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
common in SLE, autoimmune ... microsomal) - Autoimmune ... biliary cirrhosis (PBC ... Endomyseal antibody (EMA ... diagnosis #table #rheumatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... Other: NAFLD, Autoimmune ... #Diagnosis #Causes ... Acute #algorithm #hepatology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... - Differential ... disorders (e.g. autoimmune ... Myelofibrosis (MF ... #hematology #secondary
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
EBV infection, Autoimmune ... diseasesClinical ... Pylori) - Autoimmune ... NonHodgkins #comparison #oncology ... #hematology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm
Cervical:
 - Anterior
     • Infection
Causes of Localized ... Lymphadenopathy - Differential ... • Kikuchi Disease ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Cr >2 mg/dL or CC ... Causes of false- ... macroglobulinemia, and autoimmune ... MGUS #diagnosis #hematology ... #oncology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... Atypical HUS, autoimmune ... Mnemonic #diagnosis #differential ... #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Liver Enzymes - Differential ... • Ischemia • Autoimmune ... • Cholestatic disease ... Bile Ducts • PSC ... Diagnosis #Algorithm #Causes