14 results
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Drug-associated, PCH ... Defects: Sickle cell anemia ... #Diagnosis #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... esp if severe disease ... , Splenectomy, MMF ... #management #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Cold AIHA • Alloimmune ... Cold AIHA • PCH ... immune-complex hemolytic anemia ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Dyspnea - Considerations with Malignancy
Directly Malignancy Related:
 - Lymphangitic spread to lung
 - Malignant pleural effusion
metastases Treatment ... Radiation induced disease ... : - Heart valves ... - Cytopenias (anemia ... #diagnosis #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
5) Symptoms of anemia ... chemotherapy for low-risk disease ... marrow failure with anemia ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral infection, autoimmune ... • Symptoms of anemia ... CLL (older) • Autoimmune ... pts) Differential ... #hematology #diagnosis
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Corticosteroid use • Autoimmune ... diseases • Chemotherapy ... appreciate the value ... #differential # ... neutrophil #WBC #CBC #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... • Non-autoimmune ... Malignancy (e.g. hematologic ... deficiencies • Autoimmune ... lymphopenia, low PLT • Anemia
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... number of sites of disease ... Hodgkin Lymphoma Treatment ... classification #hematology ... #oncology #management