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diagnosis hepatology algorithm lfts causes elevation hepatitis elevated hepatocellular management abnormal acidosis acute aih alkaline arterial autoimmune biliary chemistry cholangitis
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Injury ... Liver Injury? ... • R value = (ALT ... #Transaminitis ... #diagnosis #differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Algorithm for Transaminitis ... def, Wilson's, Cholestatic ... dz Cholestatic
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
≥ 3x ULN Cholestatic ... ≥ 2x ULN R Value ... injury Sinai ... LFTs #Elevation #Transaminitis ... #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... • Liver injury ... disease • If ALP ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Injury: • ALP ... disease - If ALP ... #differential #
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... phosphatase) 2) Cholestatic ... Injury Differential ... #Injury #Differential
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
) Elevation - Differential ... disturbance (obstructed liver ... Highest • Bone • Liver ... of Intrahepatic cholestasis ... - Pruritis - Cholestasis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Thrombus, Vasospasm Cholestatic ... Hepatitis, TB Cholestatic ... #Injury #Differential ... Acute #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Others • Cholestatic ... disease US — Normal ... Bile Ducts • PSC
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
disease 6-9 mo ... Calculate R-Value ... Mixed DILI • Cholestatic ... #differential # ... gastroenterology #hepatology
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