12 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential ... Cold AIHA • Alloimmune ... Cold AIHA • PCH ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Drug-associated, PCH ... Diagnosis #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic ... , Splenectomy, MMF ... BrighamMedRes #AIHA #Autoimmune ... AIHA #Treatment #management ... #hematology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... Other: NAFLD, Autoimmune ... Celiac Disease Hepatocellular ... Acute #algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Liver Injury - Differential ... Celiac disease • Autoimmune ... : Autoimmune hepatitis ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Thrombocytosis - Differential ... iron deficiency, hemolysis ... disorders (e.g. autoimmune ... Myelofibrosis (MF ... Diagnosis #Causes #hematology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Calculate R-Value ... • Hepatocellular ... Idiosyncratic #differential ... gastroenterology #hepatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral infection, autoimmune ... CLL (older) • Autoimmune ... younger pts) Differential ... Hemoglobinuria (PCH ... #anemia #hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... ALP) • R > 5: Hepatocellular ... Bilirubin: RBC (hemolysis ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
fibrosis score with values ... 4, fibrosis-4; HCC ... , hepatocellular ... algorithm #Referral #Management ... #Hepatology