12 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Injury (DILI) ... Calculate R-Value ... • Hepatocellular ... #differential # ... gastroenterology #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Injury Hepatocellular ... Liver Injury ... • R value = (ALT ... Transaminitis #diagnosis #differential ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... Acute Liver Injury ... #differential # ... diagnosis #algorithm #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
abnormality vs bone Bili ... ALP ≥ 2x ULN R Value ... injury >2 ... 2: Cholestatic injury ... Transaminitis #diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Injury - Differential ... Diagnosis Hepatocellular ... Celiac Disease Hepatocellular ... #Injury #Differential ... Acute #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... ALP) • R > 5: Hepatocellular ... ALP: Typical of hepatocellular ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
LFTs) - Normal Values ... bilirubin (Conjugated/DBili ... intrahepatic cholestasis, hepatocellular ... injury, genetic ... Interpretation #diagnosis #hepatology
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
fibrosis score with values ... 4, fibrosis-4; HCC ... , hepatocellular ... algorithm #Referral #Management ... #Hepatology
Liver Abscess and Mimics - Differential Diagnosis
Most Common: Polymicrobial, E Coli, Klebsiella, Strep/Enterococcus, Staph, Anaerobes
Infectious Differential:
Liver Abscess and ... Non-Infectious: HCC ... #Abscess #Differential ... #Diagnosis #hepatology ... #management
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
- Typically hepatocellular ... pattern of liver ... injury, though ... reported (eg AIH-PBC ... #Hepatology