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diagnosis algorithm lfts transaminitis causes acute dili elevated gastroenterology lactate abnormal acidosis aclf aih alcoholic arld ascites autoimmune chemistry cholestatic
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Diagnosis Hepatocellular ... HSV • Toxic: Alcohol ... #Injury #Differential ... Acute #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury - Differential ... Injury → liver ... Liver Injury Differential ... #Liver #Injury
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Injury Hepatocellular ... Liver Injury ... • R value = (ALT ... Transaminitis #diagnosis #differential ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... ALT Ratios: • Alcoholic ... #injury #hepatitis ... diagnosis #algorithm #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Transaminitis Hepatocellular ... , PSC, Alcoholic ... Algorithm #diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... #Patterns #Liver ... #Injury #hepatology ... transaminitis #differential
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Calculate R-Value ... • Hepatocellular ... #differential # ... gastroenterology #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... Check Acute viral hepatitis ... ALT Ratios: • Alcoholic ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... Injury (DILI) ... Viral Hepatitis ... Failure #Cirrhosis #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
alternative causes • Hepatocellular ... HEV, EBV, CMV), Alcohol-related ... ascites), Chronic hepatitis ... • Autoimmune hepatitis ... #Algorithm #hepatology
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