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diagnosis algorithm lfts transaminitis acute function gastroenterology interpretation laboratory tests aclf aflp aih alcohol alcoholic arld autoimmune causes chemistry cholestatic
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... Calculate R-Value ... • Hepatocellular ... #differential # ... gastroenterology #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... #injury #hepatitis ... #differential # ... diagnosis #algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Diagnosis Hepatocellular ... Celiac Disease Hepatocellular ... #Injury #Differential ... Acute #algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... alternative causes • Hepatocellular ... • Autoimmune hepatitis ... #Liver #Injury ... Diagnosis #Algorithm #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Injury Hepatocellular ... Liver Injury ... • R value = (ALT ... Transaminitis #diagnosis #differential ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury - Differential ... Injury → liver ... Liver Injury Differential ... #Liver #Injury
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... Chronic Viral Hepatitis ... (>1000): • DILI ... injury) • Ischemic ... #Diagnosis #hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
abnormality vs bone Bili ... ALP ≥ 2x ULN R Value ... injury >2 ... 2: Cholestatic injury ... Transaminitis #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... ALP) • R > 5: Hepatocellular ... Check Acute viral hepatitis ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Alcohol-Associated Hepatitis ... Injury (DILI) ... Viral Hepatitis ... Procedures Management ... Failure #Cirrhosis #Hepatology
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