18 results
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
Anemia - Underproduction ... chronic kidney disease ... disorder - TSH, LFTs ... Underproduction #Algorithm #hematology ... #diagnosis #differential
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell anemia ... #Diagnosis #hematology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... symptoms of liver disease ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Liver Enzymes - Differential ... • Cholestatic disease ... Bile Ducts • PSC ... • Others #LFTs ... #Hepatology #LiverEnzymes
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis - Differential ... Cold AIHA • PCH ... immune-complex hemolytic anemia ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
fibrosis score with values ... markers such as ELF ... 4, fibrosis-4; HCC ... algorithm #Referral #Management ... #Hepatology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic Anemia ... esp if severe disease ... , Splenectomy, MMF ... AIHA #Treatment #management ... #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... younger pts) Differential ... #hemolytic #anemia ... #hematology #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... PT, aPTT(liver disease ... changes), high MCV anemia ... gastric bypass), LFT ... (liver disease)
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... hallmark for the disease ... If the value is ... result in severe anemia ... WBC count and differential