14 results
diagnosis algorithm injury causes hematology rheumatology transaminitis acute aih antibodies associations autoantibodies biliary chemistry cholangitis cirrhosis dili diseases drug fattyliver
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Other: NAFLD, Autoimmune ... Malignancy, 1° PBC ... #Injury #Differential ... Acute #algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Autoimmune hepatitis ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... diagnosis #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Ischemia • Autoimmune ... • Cholestatic disease ... • Alcoholic hepatitis ... • Others #LFTs
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... Other: NAFLD, Autoimmune ... #Diagnosis #hepatology ... Transaminitis #LFTs ... #hepatitis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Drug-associated, PCH ... Defects, Drugs, Liver
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... hepatitis Anti-CCP ... Dermatomyositis Anti-LKM (liver ... biliary cirrhosis (PBC ... Endomyseal antibody (EMA
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... disease: > 2 ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
cholestasis → Cirrhosis/Liver ... or higher • Liver ... bile ducts Differential ... Diagnosis: • Viral hepatitis ... diagnosis #workup #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... from subclinical disease ... to acute liver ... reported (eg AIH-PBC ... #Hepatology
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