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diagnosis algorithm hematology causes workup alkaline alp arterial associations autoantibodies biliary cholangitis cirrhosis dili diseases disorders elevation embolism fattyliver gastroenterology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... Highest • Bone • Liver ... Cholestasis - Drugs ... - Primary biliary ... Diagnosis #Algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
• Antithyroid antibodies ... or higher • Liver ... bile ducts Differential ... , Sarcoidosis, Drug-induced ... diagnosis #workup #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Cholestatic disease ... • Others #LFTs ... #Hepatology #LiverEnzymes
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... , PCH, Evans Syndrome ... , Liver Disease, ... #Diagnosis #hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anti-histone - Drug-induced ... Dermatomyositis Anti-LKM (liver ... , Anti-gp210 - Primary ... biliary cirrhosis (PBC ... #rheumatology #antibodies
Non-alcoholic fatty liver disease algorithm. For those patients with NAFLD or liver disease of unknown aetiology,
fibrosis score with values ... markers such as ELF ... 4, fibrosis-4; HCC ... algorithm #Referral #Management ... #Hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
disease, decrease ... anti-phospholipid antibodies ... gastric bypass), LFT ... (liver disease) ... unclear, or if a primary
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Myeloproliferative disease ... • Intravenous Drug ... Pregnancy • Drugs ... Syndrome, Ischemic Liver ... Antiphospholipid antibodies
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