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diagnosis liver algorithm interpretation causes chemistry dili extravascular function idiosyncratic induced intravascular laboratory management rvalue tests transaminitis values
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... delayed HTR • Drug-induced ... Cold AIHA • PCH ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced ... Chronic - ongoing ↑ LFTs ... Calculate R-Value ... Idiosyncratic #differential ... #hepatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... , PCH, Evans Syndrome ... #Differential # ... Diagnosis #hematology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
) - Normal Values ... hepatocellular injury ... Overproduction (hemolysis ... impaired uptake (drugs ... Interpretation #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
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