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diagnosis hepatology algorithm lfts causes transaminitis elevation hepatitis management acute classification elevated hematology hepatocellular interpretation laboratory lactate orthopedics workup abnormal
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Injury Hepatocellular ... Liver Injury ... Liver Injury? ... • R value = (ALT ... Transaminitis #diagnosis #differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Acute Liver Injury ... epithelia: - Cholestasis ... #differential #
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Thrombus, Vasospasm Cholestatic ... , 1° PSC, Cystic ... Hepatitis, TB Cholestatic ... #Injury #Differential
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
ALT ≥ 3x ULN Cholestatic ... ALP ≥ 2x ULN R Value ... Hepatocellular injury ... pattern ≤2: Cholestatic ... injury Sinai
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... RNA • R < 2: Cholestasis ... injury < 26 weeks ... hepatocellular injury ... chemistry #diagnosis #differential
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... dose dependent injury ... Calculate R-Value ... Mixed DILI • Cholestatic ... #differential #
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... def, Wilson's, Cholestatic ... dz Cholestatic ... , PSC, Alcoholic
Table of Causes of Acute Liver Injury #Diagnosis #Hepatology #Acute #Liver #Injury #Causes #Differential #Incidence #Table #Failure
Table of Causes ... of Acute Liver Injury ... #Injury #Causes ... #Differential # ... Incidence #Table
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... phosphatase) 2) Cholestatic ... Injury Differential ... #Injury #Differential
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... disturbance (obstructed liver ... Highest • Bone • Liver ... of Intrahepatic cholestasis ... - Pruritis - Cholestasis
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