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algorithm causes hematology lfts acidosis acute arterial chemistry classification dili elevation embolism function gastroenterology hemolysis idiosyncratic induced laboratory lactate lactic
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Liver Injury (DILI ... Calculate R-Value ... #differential # ... gastroenterology #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Diagnosis Hepatocellular ... , Recreational Drugs ... #Injury #Differential ... Acute #algorithm #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
LFTs) - Normal Values ... and Interpretation ... hepatocellular injury ... impaired uptake (drugs ... #diagnosis #hepatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... HELLP - Grafts, Valves ... , PCH, Evans Syndrome ... , Liver Disease, ... #Diagnosis #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
- Interpretation ... of LFTs R-value ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Diagnosis Framework ... • Intravenous Drug ... Pregnancy • Drugs ... Syndrome, Ischemic Liver ... Vasculitis • Injury
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... to bolus these values ... or renal injury ... circulation If drugs ... Injury: • Reduced
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