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hematology management algorithm causes criticalcare lactic treatment agglutinin anesthesia anesthesiology cardiacarrest checklist classification cold dehydrogenase disease elevated elevation extravascular foamed
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... formerly known as ... organ or stem cell ... anemia" • HELLP ... Catastrophic APLS BCM IM
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Defects: Sickle cell ... anemia, Thalassemias ... Haptoglobin ↓ - Lactate
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... • Sickle cell ... anemia • ... Prosthetic heart valves
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... - Prosthetic valves ... #diagnosis #Laboratory
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... anemia • Cold ... Hyperbilirubinemia • Elevated lactate ... younger pts) Differential ... Disorders Such As
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... elevation Serum lactate ... WBC count and differential ... #Workup #Hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
- Differential ... e.g., uptake by cells ... to bolus these values ... 30mmHg) - Severe anemia ... #Elevation #Differential
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
- Differential Diagnosis ... Shock, Severe Anemia ... Beta-Agonists, ↑ work ... Difficult to diagnosis ... #Differential #
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Antibiotics (Bactrim, PCN ... , Cell Lysis (TLS ... injury, ischemia, hemolysis ... reabsorption) Workup ... Drives K+ into cells
Cardiac Arrest - Guidelines for Crises in Anaesthesia The probable cause is one or more of: something
breathing system valves ... toxicity (→ 3-10) Acidosis ... CardiacArrest #Checklist #Differential ... Intraoperative #Checklist #Diagnosis ... #Management #Workup
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