12 results
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... • Increased LDH ... #Hemolytic #Anemia ... #Algorithm #Differential ... #Causes #Workup
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... ) - Differential ... Diagnosis Framework ... - Prosthetic valves ... #diagnosis #Laboratory
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... formerly known as ... organ or stem cell ... anemia" • HELLP ... Catastrophic APLS BCM IM
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Defects: Sickle cell ... anemia, Thalassemias ... Haptoglobin ↓ - Lactate
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential ... Diagnosis Algorithm ... • Sickle cell ... anemia • ... Prosthetic heart valves
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
If the value is ... elevation Serum lactate ... dehydrogenase (LDH ... WBC count and differential ... #Workup #Hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... anemia • Cold ... Hyperbilirubinemia • Elevated lactate ... younger pts) Differential ... Disorders Such As
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... e.g., uptake by cells ... www.ncbi.nlm.nih.gov/pmc ... to bolus these values ... 30mmHg) - Severe anemia
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... muscle, Kidneys • LDH ... intestines, White blood cells ... liver #chemistry #diagnosis ... #differential #
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Redistribution: Acidosis, Cell ... injury, ischemia, hemolysis ... reabsorption) Workup ... (acidosis), CK+LDH ... Drives K+ into cells