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Guidelines Directed medical therapy for Heart Failure Satyendra Dhar, MD, @DharSaty #HFrEF #GDMT #sodium-glucosecotransporter-2inhibitors #SGLT2i #reninangiotensinaldosteronesysteminhibitors
#PARADIGM-HF #EMPEROR-Reduced
Thiazide induced Hyponatremia - Pathophysiology • Reduced distal delivery • Inhibition of the NCC (dilution capcity)-
Thiazide induced ... Pathophysiology • Reduced ... mechanism • Reduced ... #Thiazide #induced
Causes of Hyperkalemia - Differential Diagnosis Algorithm • Increased Intake • Reduced Excretion (IV potassium with
Increased Intake • Reduced ... potassium with reduced ... #Hyperkalemia #Nephrology
Selected Clinical Trials of SGLT2 inhibitors in CVD and CKD EMPA-REG OUTCOME - Empagliflozin lowered CV events
EMPEROR-REDUCED
Hyperkalemic Distal Renal Tubular Acidosis (RTA) Type 4 - Failure to acidify urine in collecting duct
collecting duct due to reduced ... Either due to - Reduced ... Diagnosis #Management #Nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Pain/Post-op • Neurologic ... Nephrotic syndrome • Reduced ... #Hyponatremia #Nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Pain/Post-op • Neurologic ... Nephrotic syndrome • Reduced ... #Hyponatremia #Nephrology
Characteristics of Commonly Used Phosphate Binders Aluminum - Potent and effective - Useful for
hypercalcemia - Reduces ... turnover disease - Reduced ... absorption - Reduced ... edgarvlermamd - Nephrology ... #Pharmacology #Nephrology
Mechanisms of nephron damage in cardiorenal syndrome • Increased renal interstitial pressure • Hypoperfusion • Reduced
Hypoperfusion • Reduced ... congestion • Reduced ... pathophysiology #nephrology
Drug-Induced Acute Kidney Injury - Sites of Action Along the Nephron #DrugInduced #AcuteKidneyInjury #AKI #Nephrology #Pathophysiology #Pharmacology
Drug-Induced Acute ... AcuteKidneyInjury #AKI #Nephrology
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