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lupus sle systemic differential causes hematology treatment acidosis activation antinxp2 antinxp2dm apml cerebritis classification cns crisis dermatology dermatomyositis differentiation elevation
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
50%): Pleurisy / effusion ... Demyelinating syndromes ... Abdominal pain (20%) Renal ... signs #symptoms #diagnosis ... #rheumatology
Hypermagnesemia - Etiologies by Mechanism Renal Failure Excessive Mg Administration - Massive PO intake
by Mechanism Renal ... (e.g. eclampsia ... - Tumor lysis syndrome ... #Differential #Diagnosis ... Table #Causes #Management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... Lungs: • Pleural effusions ... APLA/LAC: • Renal ... #Diagnosis #Rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... Demyelinating Syndrome ... Lumbar Puncture, EEG ... CNS #neurology #rheumatology ... #management #treatment
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Syndromes - OnePager ... Syndromes (PRS) ... LVEF, pericardial effusion ... recent DAN) • EMG ... #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Prednisone 5mg/kg ... HoTN, edema and effusions ... Anaphylaxis, Acute Renal ... #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... systemic lupus erythematosus ... • Infection (eg ... #Diagnosis #Management ... #Hematology #Rheumatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
- Differential Diagnosis ... / hypoxemia -> focus ... laboratory or diagnostic ... - Compartment syndrome ... deficiency - Renal
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
thickening or effusion ... cirrhosis: 3%-20% Renal ... Distal (Type I) renal ... #Rheumatology # ... Diagnosis #Management
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