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lupus systemic hematology acidosis activation anesthesia anesthesiology causes cerebritis checklist classification cns differential differentiation elevation hypertension intraoperative lactate lactic macrophage
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... block • Sjogren syndrome ... diagnosis #rheumatology ... #management
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
50%): Pleurisy / effusion ... Demyelinating syndromes ... Abdominal pain (20%) Renal ... #systemic #erythematosus ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... Lungs: • Pleural effusions ... APLA/LAC: • Renal ... #Diagnosis #Rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
(SLE) Clinical ... Demyelinating Syndrome ... Lumbar Puncture, EEG ... #rheumatology # ... #management #treatment
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Prednisone 5mg/kg ... HoTN, edema and effusions ... Anaphylaxis, Acute Renal ... #APML #diagnosis ... #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... systemic lupus erythematosus ... [SLE], AOSD) • ... #Diagnosis #Management ... #Hematology #Rheumatology
Intraoperative Hypertension - Guidelines for Crises in Anaesthesia Hypertension is most commonly due to inappropriate depth of
reservoir bag and APL ... – see Box C for ... overload / TURP syndrome ... drug interaction, renal ... #Management #Workup
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
- Differential Diagnosis ... again we might see ... / hypoxemia -> focus ... - Compartment syndrome ... deficiency - Renal
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... thickening or effusion ... Distal (Type I) renal ... #Rheumatology # ... Diagnosis #Management
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