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diagnosis causes differential rheumatology management erythematosus lupus peds sle activation algorithm bleeding bruising cerebritis classification cns cryoglobulinemia cryoglobulins dermatology disorders
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Iron deficiency anemia ... halt nail growth (e.g ... • Nephrotic syndrome ... #Secondary #dermatology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... inflammatory disorders (e.g ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology ... #secondary
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Classified among the secondary ... underlying disease (eg ... • Infection (eg ... with leukopenia, anemia ... Diagnosis #Management #Hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Demyelinating Syndrome ... Lumbar Puncture, EEG ... APS), Secondary ... CNS #neurology #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Type III Often Secondary ... tissue disorder (e.g ... . systemic lupus ... classification #rheumatology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
- SLE (systemic ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g ... #Causes #peds #pediatrics
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... lymphopenia, low PLT • Anemia
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Constitutional disorders, eg ... Chediak-Higashi syndrome ... drug reactions - Secondary ... Megaloblastic anemia-rare ... diagnosis #causes #hematology
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
• Presence of systemic ... Drug history, e.g ... connective tissue, e.g ... Marfan syndrome, ... #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
of the immune system ... ▪ Infections (e.g ... pro-inflammatory cytokines (e.g ... Immunosuppression (e.g ... anti-IFN-γ antibodies (e.g
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