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diagnosis differential causes bleeding elevatedmcv macrocytic macrocytosis management mcv microcytic microscopy rheumatology secondary systemic thrombocytosis activation analysis atlas blood bloodcell
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Toxic Damage (e.g ... Displacement (e.g ... Foreign Surface (e.g ... #Causes #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... , B12 deficiency ... aciduria, Drugs (e.g ... #MCV #Algorithm ... Differential #Diagnosis #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Differential Diagnosis Algorithm ... 80 fL) • Iron Deficiency ... Chronic Disease (e.g ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Differential Diagnosis Algorithm ... • Dietary Deficiency ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Differential Diagnosis Algorithm ... • Secondary (e.g ... • Early Iron Deficiency ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Differential Diagnosis Algorithm ... RBC>13 • Iron Deficiency ... (Eg Causes: Chronic ... Other • e.g ... #Causes #Hematology
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Megaloblastic Anemia ... (e.g. ... Autoimmune hemolytic anemia ... Bite cells: G6PD deficiency ... Smear #Analysis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... G6PD deficiency) ... differential #diagnosis #hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Anemia - Differential ... Diagnosis Algorithm ... Gastrectomy, WHDA syndrome ... #Anemia #Differential ... #ferritin #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... specifically: iron deficiency ... inflammatory disorders (e.g ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology
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