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diagnosis rheumatology sle systemic treatment activation arthritis bloodbank bruising causes cerebritis classification cns cryoglobulinemia cryoglobulins differential disease hcq hydroxychloroquine indications
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus ( ... Demyelinating Syndrome ... thrombosis and/or blood-brain ... Lumbar Puncture, EEG ... cerebritis #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... Shrinking lung syndrome ... vein thrombosis Hematologic
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus ... underlying disease (eg ... • Infection (eg ... #Diagnosis #Management ... #Hematology #Rheumatology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
intake) • Target blood ... Insufficient blood ... Special cases (e.g ... pharmacology #levels #lupus ... #management
Consensus Indications for Irradiated RBC Transfusions: Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused
Transfusions: Cellular blood ... disorders (DiGeorge Syndrome ... HLA-selected products (e.g ... #Indications #Hematology ... #BloodBank #Management
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
SLE (systemic lupus ... erythematosus) ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... tissue disorder (e.g ... . systemic lupus ... erythematosus ( ... classification #rheumatology
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Guillain-Barré syndrome ... GBS), systemic lupus ... erythematosus ( ... (SAMS-CI) • EMG ... myopathy #diagnosis #management
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... erythematosus ( ... : • Complete blood ... inflammatory disease (e.g ... Chemistry profile (e.g
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