16 results
diagnosis rheumatology differential causes management systemic vasculitis antibodies antinuclear autoantibodies classification neurology signs sle symptoms vasculitides activation anemia arthritis associations
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... • Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... antibodies • (-) ANA
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
erythematosus ( ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... , Interstitial Pulmonary ... #patterns #rheumatology
Small Vessel Vasculitides • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
manifestations (e.g ... Interstitial lung disease ... viruses. systemic lupus ... erythematosus, ... and Sjogren's syndrome
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus ( ... Demyelinating Syndrome ... Cerebrovascular Disease ... Lumbar Puncture, EEG ... #Erythematosus
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
ANA - Non-specific ... , e.g. ... - Vasculitis, e.g ... #diagnosis #table ... #rheumatology #
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
(e.g. oculomotor ... (AQP4-lgG disease ... ; e.g. narcolepsy ... disorders (Systemic lupus ... erythematosus,
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... . lupus, CLL, lymphoma ... (usually IgM) (e.g ... deficiencies (e.g ... differential #diagnosis #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... erythematosus ... (eg, systemic juvenile ... erythematosus [ ... • Infection (eg
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... searched for when ANA ... SLE-SSc-AlM overlap syndromes ... #erythematosus ... #table #ANA
Causes of Acute Pericarditis: Infectious; Viral: Adenovirus Coxsackie virus A and B Echovirus Epstein-Barr virus Hepatitis Human immunodeficiency
Coxsackie virus A and ... Cardiac injury (e.g ... Pericardial perforation (e.g ... Systemic lupus ... erythematosus
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