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diagnosis management differential hemeonc acquired algorithm causes chronic cll differentiation disorders emergencies eosinophil eosinophilia hemophagocytic hlh leukemia leukostasis lymphocytic lymphohistiocytosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
microglobulin Treatment ... • Richter’s Syndrome ... Transform to DLBCL, PML ... Leukemia #diagnosis #workup ... #oncology #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Induce blast cell ... Prednisone 5mg/kg ... #management #hematology ... #oncology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... adsorption onto cancer cells ... Diagnosis #Management #treatment ... #hematology #differential
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... factor (GCSF) treatments ... Workup: • Complete ... #diagnosis #hematology ... #oncology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... /µL Workup • Screen ... glucocorticoid treatment ... signs or symptoms (eg ... Differential #diagnosis #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
organ damage • Treatment ... Lysis of tumor cells ... Low calcium • Treatment ... unless worrisome EKG ... diagnosis #management #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... full infectious work-up ... days → add fungal work-up ... ): - Hematologic ... “big & sticky” cells
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
▪ Infections (e.g ... pro-inflammatory cytokines (e.g ... Immunosuppression (e.g ... anti-IFN-γ antibodies (e.g ... Diagnosis #Management #Hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
hypertension and/or drug treatment ... Constitutional disorders, eg ... Chediak-Higashi syndrome ... including white blood cell ... diagnosis #causes #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
red bone marrow, e.g ... Bone marrow Treatment ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology
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